Chromosome Aberrations and Their Relevance to Metal Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Chromosome aberrations and their relevance to metal carcinogenesis.
Scoring for structural chromosome abnormalities is one of the only practical methods available for detecting visual damage in human genetic material. Cytogenetic tests in vivo and in vitro have shown the clastogenic potential of a number of metals and metal compounds. The difficulties in in vivo studies lie in identifying a specific clastogen in an occupational setting, where simultaneous expos...
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Multiple numerical chromosome aberrations in carcinogenesis: The kidney cancer model Dear Sir, This letter summarizes the talk I gave at the 2nd Conference on Aneuploidy and Cancer: Clinical and Experimental Aspects, in Oakland, California, after the kind invitation of Peter Duesberg from the University of California, Berkeley. The conference addressed the issue of whether aneuploidy or gene mu...
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The interest in the genetic and cytological effects of cyanide was greatly stimulated by the accumulation of data which indicated that hydrogen peroxide was involved in the production of mutations and chromosome aberrations by radiations (46, 43). If hydrogen peroxide is an important cause of mutation and chromosome breakage it would be expected that by inhibiting catalase and peroxidase (the e...
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The occurrence of chromosome aberrations was studied in short-term cultured lymphocytes from nine workers exposed to arsenic at the Rönnskär smeltery in northern Sweden. In the smelter workers, 87 aberrations were found in 819 mitoses. The number of aberrations varied individually from 0 to 25 aberrations per 100 cells. In a control material 13 aberrations were found in 1012 mitoses. The freque...
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Structural chromosome aberrations or chromosome mutations represent apart from aneuploidies the most frequent pathologic findings in applied chromosome diagnostics. But they also occur as combinations of both types as in unstable rearrangements or in chaotic karyotypes of early stages of embryonic development. Depending on the indication for chromosome analysis—child with developmental retardat...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1981
ISSN: 0091-6765
DOI: 10.2307/3429230